GIST ‘s – Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Tumors (GIST) – Causes, Symptoms & Advanced Treatment

Gastrointestinal Stromal Tumors (GISTs) are rare tumors that develop in the digestive tract, most commonly in the stomach or small intestine. These tumors arise from special cells called interstitial cells of Cajal (ICCs), which help control the movement of food through the gastrointestinal (GI) system. While some GISTs grow slowly and remain harmless, others can be aggressive and cancerous, requiring timely medical attention.

Symptoms of GIST

In the early stages, GISTs often do not produce symptoms and may be found incidentally during scans or endoscopies for other issues. However, as the tumor grows, it may present with:

• Persistent abdominal pain or discomfort

• Feeling full even after small meals

• Nausea or occasional vomiting

• Blood in stool or vomiting blood

• Fatigue due to internal bleeding

• Unexplained weight loss

• A visible or palpable lump in the abdomen

Diagnosis of GIST

Accurate diagnosis is essential for effective treatment. The following tests may be recommended:

• Endoscopy/Colonoscopy – to visualize internal growths

• CT or MRI Scan – to assess size, spread, and organ involvement

• Biopsy – to confirm the diagnosis through tissue sample

• Immunohistochemistry – to detect markers like CD117 (c-Kit) or DOG1, typical of GISTs

Treatment for GIST at CM Best Gastro and Eye Care

At CM Best Gastro and Eye Care, we provide state-of-the-art care for GIST patients, focusing on minimally invasive procedures and advanced therapies tailored to individual needs.

1. Laparoscopic Surgery

Minimally invasive surgery using 3–4 small incisions for tumor removal, resulting in faster recovery, less pain, and shorter hospital stays.

2. Local Tumor Excision

A precise approach to remove the tumor along with a small margin of surrounding tissue, especially effective for small and localized GISTs.

3. Partial Gastrectomy

For tumors located in the stomach, this procedure involves removing the affected part of the stomach while preserving normal digestive function.

4. Intestinal Resection

When GISTs are located in the intestine, a portion of the bowel may be surgically removed to ensure complete tumor clearance.

5. Targeted Medical Therapy

Advanced drug therapies like Imatinib (Gleevec) are used for larger or unresectable tumors, preventing their growth by targeting specific genetic mutations.

Why Choose Dr. O.K. Prakashen for GIST Treatment?

Dr. O.K. Prakashen, a renowned gastrointestinal surgeon at CM Best Gastro and Eye Care, specializes in advanced surgical techniques for complex digestive disorders including GISTs. With a commitment to patient care, precision, and modern medical technology, Dr.O.K. Prakashen has successfully treated numerous patients with both benign and malignant gastrointestinal tumors.